Time to abandon mRNA vaccine boosters?

mRNA vaccines are a great technological advance, but the medium-term results are proving disappointing. When a virus enters a human body, it faces a formidable line of defence, known as the immune system. Various weapons are thrown at the virus, such as antibodies that bind with the virus and destroy it, and cells that can […]

Booster dose for COVID vaccination: Needed or Not?

It is well known that two doses of COVID vaccination – whether it is Pfizer, Moderna, AstraZeneca/Covishield or Covaxin – offer excellent protection against moderate and severe COVID (95-97%) but not against mild and asymptomatic disease (28%). Booster doses have been a matter of speculation since the early days of COVID vaccination when it was […]

AstraZeneca / Covishield vs Delta Variant, and Timing of 2nd dose of vaccine

The delta variant of SARS-COV2 is estimated to be 30-100% more transmissible than other prevalent variants and cause more severe infections than the original alpha-variant. At last count, it has spread to 80 countries and has rapidly become the dominant strain in several countries such as India and UK. Some concerns were expressed that the […]

AstraZeneca – Covishield delayed booster: Classic case of using bad science in the Lancet to make politically convenient decisions

“Modelling analyses showed an increase in vaccine efficacy after two standard doses from 55·1% (95% CI 33·0 to 69·9) with an interval of less than 6 weeks to 81·3% (60·3 to 91·2) with an interval of at least 12 weeks. A single standard dose had an efficacy against symptomatic COVID-19 in the first 90 days […]